The Nairobi Water and Sewerage Company (NWSC) has named several estates that will go without this week.
The shortage will mainly impact estates along Mombasa road.
The shutdown, which will be between Thursday and Friday, is a result of the ongoing construction of the Nairobi Expressway.
Nairobi Water Managing Director Engineer Nahashon Muguna said the water pipeline's closing down would facilitate interconnection of the new and old water pipelines at Lang'ata Road and Mombasa Road junction.
The interconnection will enable the release of the road median to the Expressway road constructor from Nyayo Stadium to Isuzu East Africa.
Estates set to be affected by the water pipeline's closing down include Nairobi West, South B, and South C Estates, including Mater Hospital.
Others are estates along Jogoo Road, including Buruburu, Makadara, and Hamza, and the whole of the Industrial Area.
Estates along Mombasa Road from Nyayo Stadium, including Jomo Kenyatta International Airport (JKIA), Standard Gauge Railway (SGR), Athi River Export Processing Zone (EPZ), Coca Cola, Mukuru, Imara Daima, North Airport Road, and Embakasi.
"Nairobi City Water and Sewerage Company Limited will shut down water supply pipeline along Mombasa Road starting 6 am Thursday, December 17, 2020, to 6 am Friday, December 18, 2020," said the notice published on local dailies.
"We appeal to our customers for indulgence and also urge them to use available water sparingly as we work towards restoring the supply," added the notice.
Water disruptions in Nairobi have been frequent as Nairobi Water grapples with meeting the water demands by the residents.